"

Cookies ussage consent

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

I agree, do not show this message again.

Biocompatible structures based on hybrid organic-inorganic nanocrystalline materials

R. M. PITICESCU1,* , L. M. POPESCU1, M. GIURGINCA2, G. C. CHITANU3, G. NEGROIU4

Affiliation

  1. National R&D Institute for Nonferrous and Rare Metals, 102 Biruintei Bd., 077145 Pantelimon, Ilfov, Romania
  2. University POLITEHNICA Bucharest - National Consultancy Centre for Environmental Protection (UPB-CNC),1 Polizu str., Bucharest, Romania
  3. Institute for Macromolecular Chemistry “Petru Poni”, 41A Grigore Ghica Voda. St., 770487, Iasi, Romania
  4. Institute of Biochemistry, Romanian Academy, 296 Splaiul Independentei, Bucharest, Romania

Abstract

Finding new biomaterials for regenerative medicine is a major challenge to researchers working in the fields of materials science and health. Some of the most significant advances in biomaterials over the last 20 years have been referred to hybrid organic-inorganic compounds. Here we study the influence of organic synthetic polymers on biocompatible properties of hybrid nanostructured materials prepared by hydrothermal synthesis. The bonding between organic phase and inorganic phase, represented by hydroxyapatite or other calcium phosphates, takes place in situ during hydrothermal treatment. Maleic anhydride copolymers form hydrogen bonds with P=O group of inorganic phase. The bonding between organic polymers and hydroxyapatite, as well as chemical composition, cristallinity and microstructure were revealed by spectral methods such as Fourier -Transformed infrared (FT-IR) , structural characterization by X ray diffraction analysis (XRD), and scanning electron microscopy (SEM). The proliferation of human fibroblasts on the nanocomposite surface performed by in vitro tests demonstrated the biocompatible properties of this hybrid nanostructured material..

Keywords

Polymer/ceramic nanocomposites, Biocompatible structures, In vitro tests.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

R. M. PITICESCU, L. M. POPESCU, M. GIURGINCA, G. C. CHITANU, G. NEGROIU, Biocompatible structures based on hybrid organic-inorganic nanocrystalline materials, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3340-3345 (2007)