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Bioglass –polymer thin coatings obtained by MAPLE for a new generation of implants♣

F. SIMA1,* , C. RISTOSCU1, A. POPESCU1, I. N. MIHAILESCU1, T. KONONENKO2, S. SIMON3, T. RADU3, O. PONTA3, R. MUSTATA4, L.E. SIMA4, S.M. PETRESCU4

Affiliation

  1. National Institute for Lasers, Plasma, and Radiation Physics, PO Box MG-54, RO-77125 Bucharest-Magurele, Romania
  2. Natural Sciences Center, General Physics Institute, Moscow, Russia
  3. Babes-Bolyai University, Faculty of Physics & Institute for Interdisciplinary Experimental Research, Cluj-Napoca 400084, Romania
  4. Institute of Biochemistry, Romanian Academy, Splaiul Independentei 296, Bucharest, Romania

Abstract

We report on the transfer of novel PMMA-bioglass composites by matrix assisted pulsed laser evaporation to uniform thin layers onto chemically etched Ti. The targets were prepared by freezing in liquid nitrogen after dissolution in chloroform of mixtures containing PMMA reinforced with either 6P57 or 6P61 bioglass powders. The cryogenic targets were submitted to multipulse ablation with an UV KrF* (λ=248 nm, τ ~ 25 ns) excimer laser source. The fluence was set after optimization at 0.55 Jcm -2. The morphology of synthesized coatings was investigated by scanning electron microscopy and atomic force microscopy. The deposited nanostructures evidenced rather uniform and compact morphologies and consisted of droplets in the micrometric range. The composition was monitored by energy dispersive spectroscopy, Fourier transform infrared spectrometry and X-ray photoelectron spectroscopy. The presence of both PMMA and bioglass cations was evidenced in all deposited structures. Cell proliferation after cultivation on the deposited layers was studied by fluorescence microscopy. The cells were shown in both cases to cover almost entirely the structures with which they strongly interact, as proved by the pseudopodia deeply infiltrating into the composite material. The difference in density proves that cells find a more friendly living medium on glasses with a lower silica content..

Keywords

PMMA-bioglass composites, thin coatings, cells proliferation, MAPLE.

Submitted at: Nov. 5, 2008
Accepted at: Sept. 9, 2009

Citation

F. SIMA, C. RISTOSCU, A. POPESCU, I. N. MIHAILESCU, T. KONONENKO, S. SIMON, T. RADU, O. PONTA, R. MUSTATA, L.E. SIMA, S.M. PETRESCU, Bioglass –polymer thin coatings obtained by MAPLE for a new generation of implants♣, Journal of Optoelectronics and Advanced Materials Vol. 11, Iss. 9, pp. 1170-1174 (2009)