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Cold laser, hyaluronic acid, platelet-rich plasma: save the best for last in treating early phases of osteoarthritis

ANDREI VISOIANU1, GABRIELA SOARE1, RAZVAN ENE1, GHEORGHE ION POPESCU1, COSMIN CONSTANTIN BACIU1,* , CONSTANTIN RIZEA2

Affiliation

  1. "Carol Davila" University of Medicine and Pharmacy Bucharest 050474, Romania
  2. ROXY VETERINARY S.R.L., Magurele, 77125, Romania

Abstract

Optoelectronic devices and techniques are widely, and deeply, involved in natural sciences research, with high achievements in biology, biochemistry, biophysics, medicine, and healthcare. This work deals with particular aspects of optoelectronics and optics as means of healthcare in a particular rheumatic disease - knee osteoarthritis. In the early stages, noninvasive medical aids, e.g., cold laser (low level laser) therapy, drug treatment, and synthetic (hyaluronic acid), or biological (platelet-rich-plasma) intra-articular substances can be used for pain relief. Visible light (650 nm, red) from a 35mW power laser has been used to test the light effect on ex vivo damaged pig cartilage samples as such, and on similar ones, which were injected with hyaluronic acid. Samples of both categories had been first injected with silver nanoparticles to enable image enhancement through a confocal microscope, aimed to evidence changes in the morphology of the structure. The light-plasmon interaction is known for its amplification effect. In this work, it brings a wave of novelty in diagnosis, and monitoring, through microscopy, viewing the combination with hyaluronic acid. Also, a comparative study, ran for evaluation from both a functional, and a symptomatic perspective of hyaluronic acid versus platelet-rich plasma administration in human patients with early-stage osteoarthritis, shows that the latter would provide a long-term solution. Cold laser therapy replaces any anti-inflammatory aid..

Keywords

Cold laser therapy, Platelet-rich-plasma, Hyaluronic acid, Confocal microscopy, Surface plasmon, AgNPs, Intra-articular injection, Osteoarthritis knee.

Submitted at: April 8, 2025
Accepted at: April 15, 2025

Citation

ANDREI VISOIANU, GABRIELA SOARE, RAZVAN ENE, GHEORGHE ION POPESCU, COSMIN CONSTANTIN BACIU, CONSTANTIN RIZEA, Cold laser, hyaluronic acid, platelet-rich plasma: save the best for last in treating early phases of osteoarthritis, Journal of Optoelectronics and Advanced Materials Vol. 27, Iss. 3-4, pp. 176-183 (2025)