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Evaluation of Si nanowire as biosensing device

M. FLORESCU1,* , W. HU2

Affiliation

  1. Faculty of Medicine, Transilvania University of Brasov, Str. N. Balcescu 56, 50019, Brasov, Romania
  2. Electrical Engineering Department, University of Texas at Dallas, Richardson TX 75080, USA

Abstract

Using devices, such biosensors, employing biomolecules as analytical tools offer advantages compared with conventional methods due to of their simplicity, specificity, selectivity and quick response for real-time analysis. Si nanowire (SiNW) biosensors have recently emerged as a unique electronic biosensor platform for detecting biochemical species with ultrahigh sensitivity and rapid detection time. Despite of the great achievements in this field, the SiNW sensor reliability is seldom studied, which is however of vital importance for the technology to become practically relevant. The distribution of the protein molecules on biosensor surface is a function of the environmental variables, especially buffer used for sample preparation, as well as the interaction with other biomolecules. We report the effects of ion strength, liquid flow rate set by the pressure applied, and device biasing voltage on the response and stabilization times, drifting, sensitivity, and hysteresis of pH sensing of the Si nanowire bio-FETs. Using pH sensing as the model, we found some of these factors are correlated and must be controlled in order to obtain reliable sensing..

Keywords

bio-FET, biosensors, SiNW, bioactivity.

Submitted at: April 9, 2015
Accepted at: June 24, 2015

Citation

M. FLORESCU, W. HU, Evaluation of Si nanowire as biosensing device, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 7-8, pp. 1092-1098 (2015)