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Femtosecond laser machined miniaturized micro device for serum separation in bio-sensing applications

R. INDHU1,* , S. RADHA1, E. MANIKANDAN1, B. S. SREEJA1, RAVI NATHURAM BATHE2

Affiliation

  1. Department of ECE, SSN College of Engineering, Chennai– 603110, India
  2. International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), Hyderabad- 500005, India

Abstract

This paper presents the fabrication of miniaturized microfluidic device based on cyclic olefin polymer for the separation of serum from blood. The characteristics and performance of the proposed micro-holes array are analyzed for its trapping of red blood cell, serum separation and cholesterol presence using FEM numerical simulation. An array of micro-holes are created on biocompatible cyclic olefin polymer using femtosecond laser ablation. A single track of experiments has been carried out to obtain the required depth of 2microns with a diameter ranging from (8-27)µm for various Fluence levels of the incident laser beam. The surface morphology is characterized using optical microscopy images. The fabricated device is tested for its characteristics in real time in a clinical laboratory. The obtained results match well with the simulation results..

Keywords

Microfluidics, COP, Serum, Trapping, Laser, Ablation.

Submitted at: Nov. 12, 2018
Accepted at: April 8, 2019

Citation

R. INDHU, S. RADHA, E. MANIKANDAN, B. S. SREEJA, RAVI NATHURAM BATHE, Femtosecond laser machined miniaturized micro device for serum separation in bio-sensing applications, Journal of Optoelectronics and Advanced Materials Vol. 21, Iss. 3-4, pp. 238-243 (2019)