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Free radicals detection by ESR PBN spin-trap technique

G. DAMIAN1,* , D. PETRISOR1, V. MICLAUS2

Affiliation

  1. Faculty of Physics, Dept. of Biomedical Physics, “Babes-Bolyai” University, 400084, Cluj Napoca, Romania
  2. Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai” University, 400028 Cluj Napoca, Romania

Abstract

The formation and reaction of hydroxyl radicals in γ-irradiated Metoclopramide (4-amino-5-chloro-N-[2-(diethylamino)ethyl]- 2-methoxy benzamide monohydrochloride monohydrate ) and complex Fenton reaction was studied by Electron Spin Resonance spectroscopy (ESR). Specific radicals derived from purely chemical structures and reactions were detected using N-t-Butyl- α-phenylnitrone (PBN) as spin trap. Some spectroscopic properties and suggestions concerning possible nature of the radicals are discussed..

Keywords

Free radicals, Spin trap, PBN, ESR, Metoclopramide, Fenton reaction.

Submitted at: Nov. 2, 2006
Accepted at: April 15, 2007

Citation

G. DAMIAN, D. PETRISOR, V. MICLAUS, Free radicals detection by ESR PBN spin-trap technique, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 4, pp. 1010-1013 (2007)