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High pressure synthesis procedure to obtain nanostructured composites for regenerative medicine

L. M. POPESCU1, A. MEGHEA2, R. M. PITICESCU1,* , E. VASILE3

Affiliation

  1. National R&D Institute for Non-Ferrous and Rare Metals, Pantelimon, judetul Ilfov, Romania
  2. National Consultancy Centre for Environmental Protection – University POLITEHNICA Bucharest (UPB-CNC) – Romania
  3. METAV C-D, Bucharest, Romania

Abstract

Traditional chemical techniques to produce materials with specific applications, for example in cosmetics, drugs, orthopaedic surgery are incredible time consuming and inefficient. Scientists are now concentrating on analyzing how nature produces a useful structure or attribute, for example structure and properties of human bone [1]. It is well known that human bone is a natural composite material made by 80% hydroxyapatite (HAp) nanocrystals and 20% collagen fibres, forming a unique structure with exceptional properties. The aim of this study is to obtain nanostructured hydroxyapatitecollagen composite by in situ hydrothermal synthesis at low temperature and different pressures. Nanostructured composites were characterized by FT-IR, SEM, HRTEM and XRD. Structure and composition of the resulted powders for various HAp:collagen molar ratios will be compared. Best synthesis parameters (composition, pressure, time, etc.) will be selected for applications in regenerative medicine or tissue engineering..

Keywords

Nanostructured composites, High pressure, Hydroxyapatite, Collagen, Regenerative medicine.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

L. M. POPESCU, A. MEGHEA, R. M. PITICESCU, E. VASILE, High pressure synthesis procedure to obtain nanostructured composites for regenerative medicine, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3354-3357 (2007)