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Hydrogels based on carboxymethylcellulose and poly (vinyl alcohol) for controlled loading and release of chloramphenicol

G. BUHUS1, M. POPA1,* , C. PEPTU1, J. DESBRIERES2

Affiliation

  1. ”Gh. Asachi” Technical University, Faculty of Chemical Engineering, Bd. D. Mangeron, nr. 71, 700050 Iasi, Romania
  2. Pau et Pays de l’Adour University, LPCP/UMR CNRS 5067-IPREM, Hélioparc Pau Pyrénées, av. President Angot, 2, 64053 Pau Cedex 09, France

Abstract

Hydrogels based on carboxymethylcellulose (CMC) and poly (vinyl alcohol) (PVA), crosslinked with epichlorohydrine in basic medium, are polymeric materials interpenetrated network type, designed for development of polymer-drug systems with sustained release. CMC and PVA are polymers (natural, respectively synthetic) characterized by biocompatibility and biodegradability, important conditions for the polymers used for medical applications. The preparation of this new type of hydrogels is aimed to obtain a new type of macromolecular supports able to include and release in a sustained way hydrosoluble drugs (chloramphenicol). By the variation of the crosslinking reaction parameters there were developed networks with different crosslinking degrees, respectively with different swelling degrees, which influence the drug loading degree. For obtaining diffusional systems, the hydrogels with maximum swelling degree, characterized, a priori, by zero order release kinetics, were selected. The same systems were characterized from the point of view of antimicrobial activity by microbiological tests..

Keywords

CMC/PVA hydrogel, Interpenetrated network, Drug delivery, Microbiological test.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

G. BUHUS, M. POPA, C. PEPTU, J. DESBRIERES, Hydrogels based on carboxymethylcellulose and poly (vinyl alcohol) for controlled loading and release of chloramphenicol, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3445-3453 (2007)