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Interaction of poloxamer F-98 with free standing phospholipid films♣

G. AS. GEORGIEV1,* , A. G. JORDANOVA2, G. R. IVANOV3, Z. I. LALCHEV1

Affiliation

  1. Faculty of Biology, Sofia University “St. Kliment Ohridski”, 8 Dragan Tsankov Blvd., 1164 Sofia Bulgaria
  2. Institute of Biophysics, Bulgarian Academy of Sciences, 20 Georgi Bonchev Str.t, 1784 Sofia, Bulgaria
  3. Advanced Technologies Ltd., compl. Yavorov, bl. 38/B, 1111 Sofia, Bulgaria

Abstract

The interaction of poloxamer F-98 with dimiristoylphosphatidylcholine (DMPC) is investigated experimentally at one (monolayer) and two interacting air/water interfaces (foam film). Monolayer tensiometry reveals the degree of co-polymer penetration in DMPC monolayers and the alterations in monolayer compression/decompression behaviour. The changes in the film morphology are registered by Brewster angle microscopy (BAM). Foam film experiments show that the steric disjoining pressure arising in presence of Poloxamer F-98 results in increase of film equivalent water thickness and stability. It is found that the interaction between the co-polymer and DMPC molecules, both in monolayers and foam films, strongly alters the interfacial properties of the mixed systems, and bears promise for the development of new drug carrier formulations..

Keywords

Thin films, poloxamer F-98, phospholipid, “stealth” drug carriers.

Submitted at: Nov. 5, 2008
Accepted at: Sept. 9, 2009

Citation

G. AS. GEORGIEV, A. G. JORDANOVA, G. R. IVANOV, Z. I. LALCHEV, Interaction of poloxamer F-98 with free standing phospholipid films♣, Journal of Optoelectronics and Advanced Materials Vol. 11, Iss. 9, pp. 1241-1243 (2009)