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IR, NMR and EPR investigation of iron recognizing molecule - desferrioxamine B

O. COZAR1,* , N. LEOPOLD1, M. TOMOAIA-COTIŞEL2, A. MOCANU2, C. JELIC1

Affiliation

  1. Babeş-Bolyai University, Faculty of Physics, Kogălniceanu 1, RO-400084, Cluj-Napoca, Romania
  2. Babeş-Bolyai University, Faculty of Chemistry, Arany Janos 11, RO-400028, Cluj-Napoca, Romania

Abstract

IR, NMR and EPR spectroscopies were used for the structural investigation of the chelator desferrioxamine B and its Fe(III) complex, ferrioxamine B. By comparing the FT-IR absorptions of desferrioxamine B and ferrioxamine B, the structural changes due to the Fe(III) chelation were clearly deduced. Thus a resonance process in the O=C-N bond with the stabilization of C=N and C-O bonds were evidenced by chelating the Fe(III) ion. This fact is confirmed by the appearance of two new bands at 1577 cm-1 and 1043 cm-1 in the IR spectra. The homogenization of the electronic charge of the six oxygen atoms situated around the Fe3+ ion in the octahedral ferric chelate is thus achieved. 1H and 13C NMR spectra show that the high stability of octahedral DFO-Fe chelate is due to the high coordinative energy of hydroxamic acid for Fe3+ and also to the number and spacing of the coordinative groups. EPR spectra suggest that DFOB has the same ability to chelate also Mn2+ ions which have a similar electronic configuration (3d5,6S5/2) as Fe3+ ions..

Keywords

IR, NMR, EPR, Desferrioxamine B.

Submitted at: May 30, 2007
Accepted at: Dec. 7, 2007

Citation

O. COZAR, N. LEOPOLD, M. TOMOAIA-COTIŞEL, A. MOCANU, C. JELIC, IR, NMR and EPR investigation of iron recognizing molecule - desferrioxamine B, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 12, pp. 3912-3916 (2007)