"

Cookies ussage consent

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

I agree, do not show this message again.

Molecularly imprinted acrylic-based microspheres for colonic delivery of 5-aminosalicylic acid

K. ULUBAYRAM1,* , Y. TUNC1, E. BAYKARA1

Affiliation

  1. Hacettepe University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, 06100 Ankara, Turkey

Abstract

Feasibility of molecularly imprinted polymeric microspheres (MIPs) has been investigated for colonic delivery of 5- aminosalicylic acid (5-ASA). 5-ASA imprinted microspheres were prepared by a single step precipitation polymerization of 2-(diethylamino) ethyl methacrylate (DEAEMA; functional monomer) and trimethylolpropane trimethacrylate (TRIM; crosslinker). The release profiles of 5-ASA imprinted and non-imprinted microspheres were evaluated. We present a precipitation polymerization method for preparing uniform molecularly imprinted microspheres in micron range, quickly and cleanly. Monodisperse polymer particles with good spherical shapes and smooth surfaces were obtained. Furthermore, the imprinted microspheres have a slower 5-ASA release in the initial stages than the non-imprinted microspheres, because of the interaction of the drug molecules with the recognition sites in the imprinted microspheres. This result showed that molecular imprinting may have a potential for controlled delivery of drugs..

Keywords

Molecular imprinting, Colonic delivery, 5-aminosalicylic acid, Precipitation polymerization, Microspheres, 2-(diethylamino)ethyl methacrylate, Trimethylolpropane trimethacrylate.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

K. ULUBAYRAM, Y. TUNC, E. BAYKARA, Molecularly imprinted acrylic-based microspheres for colonic delivery of 5-aminosalicylic acid, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3479-3483 (2007)