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Novel solid forms of thiamine hydrochloride with succinic acid



  1. Institute of Interdisciplinary Research on Bio-Nano-Sciences, Babes Bolyai University, 400271, Cluj-Napoca, Romania
  2. Faculty of Physics, Babes-Bolyai University, 400084, Cluj-Napoca, Romania


The present study reports on new solid forms obtained from thiamine hydrochloride with succinic acid by applying the liquid assisted grinding (LAG) mechanochemical method. Samples with (1:1) and (1:2) molar ratios of thiamine hydrochloride to succinic acid resulted after two hours grounding with few drops of acetonitrile were investigated by X-ray diffraction, thermal analysis and infrared spectroscopy. Both XRD and FTIR analysis show new diffraction lines and absorption bands, respectively, denoting that there is not simply a mechanical mixture of components. The FTIR results indicate that a new salt of thiamine hydrochloride with succinic acid was obtained owing to proton transfer..


Thiamine hydrochloride, Succinic acid, Mechanochemical synthesis, XRD, FTIR, DTA/TGA.

Submitted at: July 3, 2020
Accepted at: Aug. 18, 2020


D. M. PETRISOR, M. POP-MURESAN, S. SIMON, Novel solid forms of thiamine hydrochloride with succinic acid, Journal of Optoelectronics and Advanced Materials Vol. 22, Iss. 7-8, pp. 419-424 (2020)