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Optoelectronic hyperspectral imaging system for the non-invasive detection of dysplastic nevi: a pilot study

DRAGOS MANEA1,* , MIHAELA ANTONINA CALIN1, SORIN VIOREL PARASCA2,3

Affiliation

  1. National Institute of Research and Development for Optoelectronics – INOE 2000, Magurele, Romania
  2. Emergency Clinical Hospital for Plastic, Reconstructive Surgery and Burns, Bucharest, Romania
  3. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Abstract

Optoelectronic techniques offer non-invasive tools for assessing pigmented skin lesions by quantifying wavelength-dependent interactions between light and cutaneous chromophores. This pilot study evaluated hyperspectral imaging as an objective method for identifying dysplastic features in melanocytic nevi through pixel-level analysis of melanin distribution. Ten patients with clinically diagnosed nevi located on the back, arms, legs, or neck were examined using a pushbroom hyperspectral system operating in the 400–800 nm range. Images were normalized with white and dark references, cropped to the lesion region of interest, denoised, and processed with in-house software to generate melanin concentration maps based on the modified Beer–Lambert law. The spatial uniformity of melanin distribution was quantified using semivariance, applied as a numerical indicator of local heterogeneity. Common nevi showed homogeneous melanin maps and semivariance values below 0.1, whereas histopathologically confirmed dysplastic nevi presented irregular melanin distribution and values above 0.24. These preliminary results suggest that hyperspectral imaging combined with semivariance analysis may differentiate common from dysplastic nevi objectively, without relying on artificial intelligence or large training datasets. Further validation in larger cohorts is required to establish diagnostic thresholds and clinical applicability and to determine its future potential value as a complementary screening tool in routine dermatological practice..

Keywords

Hyperspectral imaging, Dysplastic nevi, Non-invasive diagnosis, Melanin concentration maps.

Submitted at: June 9, 2026
Accepted at: Aug. 4, 2026

Citation

DRAGOS MANEA, MIHAELA ANTONINA CALIN, SORIN VIOREL PARASCA, Optoelectronic hyperspectral imaging system for the non-invasive detection of dysplastic nevi: a pilot study, Journal of Optoelectronics and Advanced Materials Vol. 28, Iss. 7-8, pp. 376-382 (2026)