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Pharmacokinetics and biodistribution of nickel oxide for liver cancer cure

MUHAMMAD FAKHAR-E-ALAM1,2, M. U. FAROOQ1, NAJEEB ABBAS2, SEEMAB IQBAL2, NASIR AMIN2, MUHAMMAD HAMMAD AZIZ3, M. ATIF4,5, W. A. FAROOQ4, R. SULEMAN6, S.S.Z. ZAIDI6

Affiliation

  1. Institute of Fundamental and Frontier Science , University of Electronics Science and Technology, China, 610054 Chengdu, Sichuan, China
  2. Department of Physics, Faculty of Science and Technology, GC University, Faisalabad, Pakistan
  3. Department of Physics, College of Science in Zulfi, Majmaah University, Saudi Arabia
  4. Department of Physics and Astronomy, King Saud University, Riyadh, Saudi Arabia
  5. National Institute of Laser and Optronics, Nilore, Islamabad, Pakistan
  6. National Institute of Health, Islamabad, Pakistan

Abstract

Use of Nickel Oxide (NiO) nanoparticles as photosensitizers has undergone a strong development in the last few years due to their ability and significant bioavailability. NiO NPs are emerging milestones in photodynamic therapy (PDT) ongoing research with diverse marvelous biomedical applications e.g. cancer diagnostic as well as treatment, in many antibacterial and microbial therapy purposes and plays a dynamic role in such applications because of their unique characteristics like size dependent tunable emission spectrum of broad wavelength of light and high quantum yield. At this time, nanodependent PDT technique involving nanoparticles and NRs is effective, sophisticated and up to the mark due to high drug accumulation in the cancerous tissue and normal safety and biosafety. The main object of current research is improving the efficiency of cancer treatment up to certain limit. In ongoing research experiment NiO NPs were grown by applying co-precipitation method. Manifold techniques were employed for justification of crystalline and morphological analysis. In first step author focused the toxic nature of suggested particles. Secondly, biotoxicity of NiO NPs were tested in hepatocellular model by applying NRA and microscopy. More sophisticated, efficient, effective and rapidly developing technique for cancer treatment is thirst of this modern age. Because many peoples due to this are under attack due to this severe disease. In addition, hepatocellular carcinoma (HepG2) is fifth the most common harmful cancer found in liver cells. Finally actual cell killing effect via necrosis/apoptosis was the big challenge for author. After careful study of toxicity of NiO NPs in HepG2 cellular model the author will be confident to interpret protocol for real treatment of liver cancer patients..

Keywords

NiO nanoparticles (NiO NPs), HepG2 cell line, Neutral red assay, Photodynamic therapy.

Submitted at: Jan. 18, 2016
Accepted at: April 5, 2016

Citation

MUHAMMAD FAKHAR-E-ALAM, M. U. FAROOQ, NAJEEB ABBAS, SEEMAB IQBAL, NASIR AMIN, MUHAMMAD HAMMAD AZIZ, M. ATIF, W. A. FAROOQ, R. SULEMAN, S.S.Z. ZAIDI, Pharmacokinetics and biodistribution of nickel oxide for liver cancer cure, Journal of Optoelectronics and Advanced Materials Vol. 18, Iss. 3-4, pp. 414-418 (2016)