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Polarization-sensitive autofluorescence spectroscopy of non-melanoma cutaneous tumours

AL. ZHELYAZKOVA1,* , E. BORISOVA1, TS. GENOVA1, E. PAVLOVA2, P. TROYANOVA2, I. TERZIEV2, N. PENKOV2, L. AVRAMOV1

Affiliation

  1. Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko Chaussee Blvd., 1784, Sofia, Bulgaria
  2. University hospital “Tsaritsa Yoanna- ISUL”, 8, “Byalo more” str., 1527 Sofia, Bulgaria

Abstract

In vivo and ex vivo point-by-point measurements of excitation-emission matrices (EEM) from skin tumours using linear polarizer and analyzer for excitation and emission light were carried out. The fluorescence spectra obtained reveal differences in spectral intensity, related to general attenuation, due to filtering effects of used polarizer/analyzer couple. Significant spectral shape changes were observed for the complex autofluorescence signal detected, which correlated with collagen and protein cross-links fluorescence, that could be addressed to the tissue extracellular matrix and general condition of the skin investigated, due to morphological destruction during lesions’ growth..

Keywords

Excitation-emission matrix, Polarization-sensitive autofluorescence, Basal cell carcinoma.

Submitted at: July 1, 2015
Accepted at: Sept. 9, 2015

Citation

AL. ZHELYAZKOVA, E. BORISOVA, TS. GENOVA, E. PAVLOVA, P. TROYANOVA, I. TERZIEV, N. PENKOV, L. AVRAMOV, Polarization-sensitive autofluorescence spectroscopy of non-melanoma cutaneous tumours, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 9-10, pp. 1283-1287 (2015)