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Potential application of CeO2/Au nanoparticles as contrast agents in optical coherence tomography

H. ULLAH1,* , Z. BATOOL1, A. NAZIR1, K. AHMED1, M. RASHEED1, FATIMAH S. AL-KHATTAF2, G. GILANIE3, MUHAMMAD UMAR DAD4, S. HABIB5

Affiliation

  1. Biophotonic Imaging Techniques Laboratory, Institute of Physics, The Islamia University, Bahawalpur, Pakistan
  2. Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
  3. Department of Artificial Intelligence, Faculty of Computing, The Islamia University of Bahawalpur, 63100, Pakistan
  4. School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China
  5. Institute of Chemistry, The Islamia University, Bahawalpur, Pakistan

Abstract

The current work explores the potential application of CeO2/Au core shell (particle size ranging between 30-40 nm) that were competently synthesized and were confirmed through characterization technique of XRD, diffuse reflectance spectroscopy, and UV-VIS spectroscopy in emerging imaging modality optical coherence tomography (OCT) as contrast agent. These nanoparticles were also successfully analyzed in water and blood plasma phantom to measure their scattering coefficients and relaxation times under dynamic light scattering in Brownian motion. The K-edge values were calculated using CeO2 NPs as core effect that have application in OCT. The Au has been observed to be a good contrast agent in OCT and have higher scattering coefficient that CeO2. The particles were formed using unique pot green function and Z, keeping PH at 7. Starch was added to target the tumour. Therefore, the current work assures that Cerium and Gold Core-Shell nanoparticles have significant applications in the improvement of OCT imaging..

Keywords

CeO2/Au, Contrast agents, XRD, Diffuse reflectance spectroscopy, UV-VIS spectroscopy, Optical coherence tomography.

Submitted at: March 14, 2022
Accepted at: July 30, 2024

Citation

H. ULLAH, Z. BATOOL, A. NAZIR, K. AHMED, M. RASHEED, FATIMAH S. AL-KHATTAF, G. GILANIE, MUHAMMAD UMAR DAD, S. HABIB, Potential application of CeO2/Au nanoparticles as contrast agents in optical coherence tomography, Journal of Optoelectronics and Advanced Materials Vol. 26, Iss. 7-8, pp. 307-315 (2024)