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Preliminary histological studies on the influence of glycerol-iron-oxide nanoparticles

C. L. POPA1, E. ANDRONESCU2,3, C. TURCULET3,4, M. BEURAN3,4, P. Le COUSTOMER5,6,7, M. L. BADEA1,8, A. SURUGIU9, A. M. PRODAN2,4,10,*

Affiliation

  1. National Institute of Materials Physics, P.O. Box MG 07, 07725, Magurele, Romania,
  2. University “Politehnica” of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1-7 Polizu Street, P.O. Box 12-1
  3. Academy of Romanian Scientists (AOSR), Splaiul Independentei 54, 050094, Bucharest, Romania
  4. Emergency Hospital Floreasca, Bucharest 5, Calea Floresca nr 8, sector 1, Bucarest, Romania,
  5. Université Bordeaux,EA CNRS 4592 Géoressources & Environnement, ENSEGID 1 Allée Daguin 33607 Pessac, France
  6. Institut des Sciences Analytiques et de Physico-Chimie pour l’Environnement et les Matériaux (IPREM), UMR 5254
  7. Université de Pau et des Pays de l’Adour/ CNRS- IPREM, Hélioparc, 2, avenue P.Angot , 64053 PAU cedex 09, France
  8. University of Agronomic Sciences and Veterinary Medicine, 59 Mărăşti Blvd., 011464, Bucharest, Romania
  9. Hospital of obstetrics and gynecology, Str. Studionului, 5, Buftea, Ilfov, 70000, Romania
  10. "Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari, sector 5, Bucharest, Romania

Abstract

This paper reports structural and morphological studies as well as in vivo evaluation of glycerol-iron-oxide nanoparticles (GIO-NPs) in order to investigate their influence on different organic tissues. Transmission electron microscopy (TEM) studies confirm the structure characteristic to iron oxide nanoparticles and their ellipsoidal shape. The histopathological examinations indicated that the studied nanoparticles induce many morphological alterations to the liver, kidneys and spleen tissues 24h, 48h and 72h exposure..

Keywords

Iron oxide, Glycerol, Histological studies.

Submitted at: Aug. 14, 2015
Accepted at: Sept. 9, 2015

Citation

C. L. POPA, E. ANDRONESCU, C. TURCULET, M. BEURAN, P. Le COUSTOMER, M. L. BADEA, A. SURUGIU, A. M. PRODAN, Preliminary histological studies on the influence of glycerol-iron-oxide nanoparticles, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 9-10, pp. 1572-1576 (2015)