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Preparation and characterization of ketoprofen-layered double hydroxide compounds

M. SILION1, D. HRITCU2, M. I. POPA1,*

Affiliation

  1. Department of Chemical Engineering, Faculty of Chemical Engineering and Environmental Protection, Technical University Iasi, Bd. D. Mangeron 71A, 700050, Iasi, Romania
  2. “P. Poni” Institute of Macromolecular Chemistry, 41A, Aleea Grigore Ghica Voda, 700487, Iasi, Romania

Abstract

Organo-mineral nanohibrid materials in which the organic moiety is intercalated inside the inorganic lamella were prepared by an ion exchange method. Ketoprofen (KET) anions were used as guest molecules, while ZnAl and MgAl layered double hydroxides (ZnAlLDH and MgAlLDH) were used as inorganic hosts. The intercalated compounds were examined by X-ray diffraction (XRD), FTIR spectroscopy, thermo gravimetric and scanning electron microscopy analysis techniques. The XRD patterns of the samples were found to be typical to those of well crystallized solids with the hydrotalcite structure. The basal spacing of the ZnAlLDH with nitrate as intergallery anion expanded from 8.74 Å to 22.36 Å upon drug intercalation. In the case of MgAlLDH the basal spacing expanded from 8.50 Å to 22.54 Å. The FTIR spectroscopy results prove the presence of the organic compound in the network structure of the synthesized hydrotalcites. The thermal stability of the intercalated KET was enhanced compared with the pure drug before intercalation. Elemental and chemical analysis of the intercalated compounds showed a good intercalation percentage, i.e. 45% for ZnAlLDH_KET and 50% for MgAlLDH_KET respectively (by weight)..

Keywords

Layered double hydroxide, Ketoprofen, ion-exchange, Organic-inorganic materials.

Submitted at: Sept. 2, 2010
Accepted at: Oct. 14, 2010

Citation

M. SILION, D. HRITCU, M. I. POPA, Preparation and characterization of ketoprofen-layered double hydroxide compounds, Journal of Optoelectronics and Advanced Materials Vol. 12, Iss. 10, pp. 2150-2156 (2010)