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Proteins adsorption to orthopaedic biomaterials: vibrational spectroscopy evidence

S. CAVALU1,* , V. SIMON2

Affiliation

  1. University of Oradea, Faculty of Medicine and Pharmacy, P-ta 1 Decembrie 10, 410068, Oradea, Romania
  2. Babes-Bolyai University, Faculty of Physics, 400084 Cluj-Napoca, Romania

Abstract

ATR FTIR spectroscopy and deconvolution techniques are applied in this work in order to obtain structural information on serum albumin and hyaluronidase upon adsorption onto orthopedic biomaterials polymethyl methacrylate. Quantitative analysis of both proteins by curve fitting to the inverted second derivative spectra of the conformationally-sensitive amide I and amide III bands indicate perturbations of both α-helix and β-sheet structures upon adsorption process..

Keywords

Orthopaedic biomaterials, Proteins, Vibrational spectroscopy.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

S. CAVALU, V. SIMON, Proteins adsorption to orthopaedic biomaterials: vibrational spectroscopy evidence, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3237-3302 (2007)