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Raman and SERS investigations of trihydrate amoxicillin

A. CALBOREAN1,* , D. MANIU1, V. CHIS1, T. ILIESCU1, V. K. RASTOGI2

Affiliation

  1. Department of Physics , Babes – Bolyai University, M.Kogalniceanu 1, 400084 Cluj -Napoca Romania
  2. Physics Department, CCS University, Meerut-250 004, India

Abstract

Raman and SERS investigations in combination with density-functional theory (DFT) were performed on the trihydrate amoxicillin (THA). The theoretical values were compared with the experimental X–ray data and Raman results. The SER spectrum of trihydrate amoxicillin molecule on silver colloid at pH value of 6 was compared with Raman spectrum and analyzed. The adsorbed molecule is bonded to the silver surface through the amino group by chemisorption process. In adsorbed state, benzene, beta-lactam and thiazolidine rings are situated at a large distance to the silver surface and for these we presume that the electromagnetic mechanism can be implied..

Keywords

SERS, SERS supports, Amoxicillin trihydrate, Density functional theory.

Submitted at: Nov. 15, 2006
Accepted at: March 15, 2007

Citation

A. CALBOREAN, D. MANIU, V. CHIS, T. ILIESCU, V. K. RASTOGI, Raman and SERS investigations of trihydrate amoxicillin, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 3, pp. 680-685 (2007)