"

Cookies ussage consent

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

I agree, do not show this message again.

Structural elucidation of chemically modified cyclodextrins and their inclusion complexes for medicine applications

M. R. CAIRA1,* , W. T. MHLONGO1, J. LI1

Affiliation

  1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

Abstract

Structural properties of selected derivatized cyclodextrins (CDs), gleaned from single crystal X-ray studies, are described with reference to the effects on molecular conformation and inclusion ability accompanying their formation from the corresponding native CDs. Species of interest include several acylated and methylated CDs as well as their inclusion complexes with drug guest molecules. As a representative example of an inclusion complex in this category for which full structural and thermal characterization has recently been achieved, that between permethylated α-CD and the antihypertensive metoprolol is presented. This inclusion complex has 2:1 host-guest stoichiometry that features novel ‘bimodal’ guest inclusion..

Keywords

Cyclodextrin, Inclusion compounds, X-ray crystal structure.

Submitted at: Feb. 25, 2008
Accepted at: Aug. 28, 2008

Citation

M. R. CAIRA, W. T. MHLONGO, J. LI, Structural elucidation of chemically modified cyclodextrins and their inclusion complexes for medicine applications, Journal of Optoelectronics and Advanced Materials Vol. 10, Iss. 9, pp. 2255-2260 (2008)