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Surface properties of segmented poly(ester urethane)s and evaluation of in vitro blood compatibility and in vivo biocompatibility

M. LUPU1, M. BUTNARU2,* , D. MACOCINSCHI1, O. Z. OPREAN3, C. DIMITRIU4, O. BREDEŢEAN2, M. ZAGNAT2, S. IOAN1

Affiliation

  1. Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania
  2. Gr. T. Popa University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Iasi, Romania
  3. Ion Ionescu de la Brad University of Agricultural Sciences and Veterinary Medicine, Iasi, Romania
  4. Gr. T. Popa University of Medicine and Pharmacy, Faculty of Medicine, Iasi, Romania

Abstract

The correlation between the surface tension parameters and the chemical composition of poly(ester urethane) and poly(ether urethane) thin films with different soft and hard segments, both before and after plasma treatment, was investigated. For all investigated films, the polar terms contribute significantly to the total surface tensions, as due to the large electron-donor, − sv γ , interactions. Plasma treatment alters the surface energy of samples by changing their surface polarity and hydrophilicity. The polyurethane samples with higher hydrophilicity were tested for the blood protein adsorption, preliminary blood compatibility analyses and the tissue compatibility. The studied polyurethane had satisfactory balance between water uptake and blood protein adsorption, thrombogenic and hemolytic proprieties. Subcutaneous implantation of polyurethanes samples showed a good tolerance for the tested material. None of the animals died and none of chronic cellular inflammatory reactions observed so the studied material may be considered to be biomaterials..

Keywords

Poly(ester urethane)s, Poly(ether urethane)s, Surface tension, Blood protein adsorption, Haemocompatibility, in vivo biocompatibility.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

M. LUPU, M. BUTNARU, D. MACOCINSCHI, O. Z. OPREAN, C. DIMITRIU, O. BREDEŢEAN, M. ZAGNAT, S. IOAN, Surface properties of segmented poly(ester urethane)s and evaluation of in vitro blood compatibility and in vivo biocompatibility, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3474-3478 (2007)