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Synthesis and characterization of new bioceramic/antibiotic composites

ZS. BENYEY1, E. VANEA1, M. TĂUŢAN2, M. SPINU2, V. SIMON1,*

Affiliation

  1. Faculty of Physics & Institute of Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania
  2. Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania

Abstract

Silica calcium phosphate bioactive glass with 60SiO2·30CaO·10P2O5 (mol %) composition was synthesized by sol-gel technique, converted by annealing to a glass-ceramic containing apatite and wollastonite nanocrystalline phases, and loaded with three different antibiotics considered to decrease the risk of infection at implantation sites. The antibiotics used were tetracycline, streptomycin and ampicillin. The loading efficiency was assessed by ultraviolet-visible (UV-Vis) and Fourier transformed infrared (FTIR) spectroscopy. The specific surface areas and the mean pore volume of the samples were investigated before and after antibiotics loading using Brunauer, Emmet and Teller (BET) method. In vitro bioactivity of unloaded and antibiotics loaded glass samples was tested in simulated body fluid. The antimicrobial ability of the bioactive glass/antibiotic composites was determined on Escherichia coli bacteria.

Keywords

Sol-gel, Bioactive glass-ceramics, Antibiotics loading.

Submitted at: Aug. 8, 2013
Accepted at: Nov. 7, 2013

Citation

ZS. BENYEY, E. VANEA, M. TĂUŢAN, M. SPINU, V. SIMON, Synthesis and characterization of new bioceramic/antibiotic composites, Journal of Optoelectronics and Advanced Materials Vol. 15, Iss. 11-12, pp. 1375-1379 (2013)