"

Cookies ussage consent

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

I agree, do not show this message again.

Synthesis of poly(vinyl alcohol) - methyl cellulose hydrogel as possible scaffolds in tissue engineering

C. IVANOV1, M. POPA1,2,* , A. A. POPA3

Affiliation

  1. „Gh. Asachi” Technical University of Iasi, Faculty of Chemical Engineering, Department of Natural and Synthetic Polymers, Bd. D. Mangeron, nr. 71 A, 700050 Iasi, Romania
  2. Clinical Hospital “Sf. Treime” Department of Neurosurgery, Str. Ateneului 2, Iasi, Romania
  3. ”Petre Andrei” University, Ghica Voda Street, no. 13, Iasi,700128, Romania

Abstract

Hydrogels have enormous potential in medical and pharmaceutical applications. Due to their biocompatibility, hydrogels have emerged as a promising option in drug delivery and tissue engineering. In this study, poly(vinyl alcohol) (PVA) and methyl cellulose (MC) interpenetrated network type hydrogels were prepared by simultaneous crosslinking, using epichlorohydrin (EPCl) as crosslinking agent. The structure of the new material was confirmed by IR spectroscopy. Swelling characteristics (maximum swelling degree, swelling rate constant) were determined, in correlation with reaction parameters and network density. A study of drug (Cefoperazone Sodium - CS) release and mechanical tests were also performed..

Keywords

Hydrogel, poly(vinyl alcohol), Methyl cellulose, Kinetical and mechanical studies.

Submitted at: March 23, 2007
Accepted at: Nov. 16, 2007

Citation

C. IVANOV, M. POPA, A. A. POPA, Synthesis of poly(vinyl alcohol) - methyl cellulose hydrogel as possible scaffolds in tissue engineering, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 11, pp. 3440-3444 (2007)