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The capture of magnetic colloids at flow regimes specific to the capillary blood vessels

L. E. UDREA1, V. BĂDESCU1,* , N. J. C. STRACHAN2, O. ROTARIU1

Affiliation

  1. National Institute of Research and Development for Technical Physics, Iasi, 700050, Romania
  2. University of Aberdeen, School of Biological Sciences, Aberdeen, AB24 3UU, United Kingdom

Abstract

Magnetic drug targeting (MDT) of tumors situated in the cavity of the human body is difficult because the magnetic field and its gradients decrease rapidly with the distance from the magnets. Here a dipolar magnetic device is used to investigate the magnetic capture of colloidal magnetic particles (MPs) in capillary tubes at flow velocities similar to that encountered in the capillary beds of tumours. The capture of MPs is influenced by the gradient of the magnetic field, the flow velocity, the particle concentration and their surface properties. This work shows the potential of MDT for targeting tumours positioned at medium distances from the surface of the body (e.g. head, neck, breast, hands and legs)..

Keywords

Magnetic drug targeting, Magnetic particles, Bipolar magnetic device, Magnetic focusing, Blood flow, Capillaries.

Submitted at: Jan. 15, 2007
Accepted at: Aug. 18, 2007

Citation

L. E. UDREA, V. BĂDESCU, N. J. C. STRACHAN, O. ROTARIU, The capture of magnetic colloids at flow regimes specific to the capillary blood vessels, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 8, pp. 2593-2601 (2007)