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The effect of pH on amino acids binding to gold nanoparticles

GH. MIHAILESCU1,* , L.OLENIC1, S. PRUNEANU1,2, I. BRATU1, I. KACSO1

Affiliation

  1. National Institute for Research and Development of Isotopic and Molecular Technologies, P.O. Box 700, 400293, Cluj- Napoca, Romania
  2. School of Science & Technology, University of Teesside, Middlesbrough Tees Valley TS1 3BA UK

Abstract

Biologically active molecules such as amino acids, peptides and proteins are usually attached to nanoparticles to improve their bio-specificity and to expand application potentialities of these types of systems in biological and medical sciences. The work reported here describes interactions between gold nanoparticles (GNP) and amino acids. The surface chemistry of particulate Au is dominated by its negative surface charge. The control of aggregation degree between amino acids and GNP is achieved by pH change of reaction environment. The aggregation process is followed by UV-Vis and IR spectroscopy. From the obtained data we calculated K- the association constants. The values of K observed in these experiments suggest a good association between GNP and amino acids. The paper presents the preliminary study in order to obtain 3D structures: GNP-amino acids with possible application as biosensors..

Keywords

Gold nanoparticles, Amino acids, Multilayers.

Submitted at: Nov. 15, 2006
Accepted at: March 15, 2007

Citation

GH. MIHAILESCU, L.OLENIC, S. PRUNEANU, I. BRATU, I. KACSO, The effect of pH on amino acids binding to gold nanoparticles, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 3, pp. 756-759 (2007)