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The guidance of magnetic colloids in simulated tissues for targeted drug delivery

O. ROTARIU1,2,* , L. E. UDREA1, N. J. C. STRACHAN2, V. BĂDESCU1

Affiliation

  1. National Institute of Research and Development for Technical Physics, Iasi, 700050, Romania
  2. University of Aberdeen, School of Biological Sciences, Aberdeen, AB24 3UU, United Kingdom

Abstract

The delivery of anticancer agents delivered by magnetic carrier particles (MP) is an exciting new prospect in treating cancer. Here an experimental model is used to investigate the physical guidance of magnetic carrier colloids through simulated tissues. Using a gradient magnetic field, it was found that magnetic particles could be dispersed within a simulated diseased tissue in < 120 minutes. This treatment time depended on the magnetic field, the MP properties and the kind of tissue (interstitial space between the cells). These results indicate that the magnetic guidance of colloids has the potential for treating sub-surface cancers within the human body..

Keywords

Magnetic drug targeting, Magnetic particles, Tissues, Agar gels.

Submitted at: Nov. 2, 2006
Accepted at: April 15, 2007

Citation

O. ROTARIU, L. E. UDREA, N. J. C. STRACHAN, V. BĂDESCU, The guidance of magnetic colloids in simulated tissues for targeted drug delivery, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 4, pp. 942-945 (2007)